Bartek borowiec biography channels

  • Jazzpospolita was created in 2008 in Warsaw by bass player Stefan Nowakowski and drummer Wojtek Oleksiak.
  • We demonstrated that homologous recombination (HR) is an important mechanism to repair rereplication-associated DSBs, and sister chromatids are used as.
  • Biphasic JNK–Erk signaling separates induction and maintenance of cell senescence after DNA damage induced by topoisomerase II inhibition.

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    Protein phosphatase 4 regulatory subunit 2 (PPP4R2) is recurrently deleted in acute myeloid leukemia and required for efficient DNA double strand break repair

    INTRODUCTION

    Recent developments in genomic techniques have tremendously improved our knowledge about the complex genomic architecture of acute myeloid leukemia (AML) and have shed further light on the genetic heterogeneity of the disease. Despite the increasing number of genetic abnormalities only a minority of these findings has entered clinical practice by displaying prognostic and predictive relevance used for risk-adapted therapeutic strategies [1–6]. Most genetic studies have been descriptive and do not clarify functional relevance of specific candidate genes located in recurrently altered genomic regions.

    Using high-resolution single-nucleotide polymorphism (SNP) analyses we have previously identified a recurrent microdeletion at chromosomal band 3p14.1-p13 in cytogenetically normal (CN-) AML [7, 8]. In addi

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    Doda (singer)

    Polish singer

    Not to be confused with Dido (singer) or Dodie.For other uses, see Doda (disambiguation).

    Doda

    Doda in 2023

    Born

    Dorota Rabczewska


    (1984-02-15) 15 February 1984 (age 40)

    Ciechanów, Poland

    Other names
    • Doda
    • Doda Elektroda
    • Dorota Rabczewska-Stępień[1]
    • Dorota Aqualiteja Rabczewska
    Occupations
    • Singer
    • songwriter
    • television personality
    Spouses

    Radosław Majdan

    ​

    ​

    (m. 2005; div. 2008)​

    Emil Stępień

    ​

    ​

    (m. 2018; div. 2021)​
    Partners
    • Adam Darski (2009–2011)
    • Błażej Szychowski (2011–2012)
    • Emil Haidar (2014–2015)
    • Dariusz Pachut (2022–2024)
    Musical career
    Genres
    Years active1998–present
    Labels

    Musical artist

    Websitedoda.net.pl

    Dorota Aqualiteja Rabczewska (Polish:[dɔˈrɔta rabˈt͡ʂɛfska]; born 15 February 1984), known professionally as Dod

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    Abstract

    The ATR-Chk1 pathway is essential in cellular responses to DNA damage and replication stress, whereas the role of long noncoding RNAs (lncRNAs) in regulating this pathway remains largely unknown. In this study, we identify an ATR and Chk1 interacting lncRNA (ACIL, also known as LRRC75A-AS1 or SNHG29), which promotes the phosphorylation of Chk1 by ATR upon DNA damages. High ACIL levels are associated with chemoresistance to DNA damaging agents and poor outcome of breast cancer patients. ACIL knockdown sensitizes breast cancer cells to DNA damaging drugs in vitro and in vivo. ACIL protects cancer cells against DNA damages by inducing cell cycle arrest, stabilizing replication forks and inhibiting unscheduled origin firing, thereby guarding against replication catastrophe and contributing to DNA damage repair. These findings demonstrate a lncRNA-dependent mechanism of activating the ATR-Chk1 pathway and highlight the potential of utilizing ACIL as a predictive biomarker f

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